当講座の主たる研究課題
硬組織の発生、再生、維持はどのようなメカニズムで行われるか？つまり分子の同定と分子間の相互作用を明らかにすることでどのように発生、再生、維持を説明できるか？

この課題のもと、下記の項目についての研究を行っている

2006年5月22日
Dr. Shun-ichi Murakami, M.D., Ph.D.
Assistant Professor
Departments of Orthopaedics and Genetics
Case Western Reserve University
FGFR3とMAPKの内軟骨性骨化における役割

2007年6月26日
中島　和久　特任教授.
東京医科歯科大学難治疾患研究所
骨芽細胞分化と転写因子

1. Ideno H, Takanabe R, Shimada A, Imaizumi K, Araki R, Abe M, Nifuji A.
Protein related to DAN and cerberus (PRDC) inhibits osteoblastic differentiation and its suppression promotes osteogenesis in vitro.
Exp Cell Res. 2008 Dec 6 [Epub ahead of print]

2. Komatsu K, Shimada A, Shibata T, Shimoda S, Oida S, Nifuji A.
Long-term effects of local treatment with alendronate on healing of replanted rat teeth.
J Periodont Res. 43(2):194-200, 2008.

3. Komatsu K, Shibata T, Shimada A.
Analysis of contribution of collagen fibre component in viscoelastic response of periodontal ligament by using enzyme probe.
J Biomech. 40(12), 2700-6, 2008.

4. Ujiie Y, Shimada A, Komatsu K, Gomi K, Oida S, Arai T, Fukae M.
Degradation of noncollagnous components by neutrophil elastase reduces mechanical strength of rat periodontal ligament.
J Periodont Res. 43(1):22-31, 2008.

5. Shimada A, Shibata T, Komatsu K, Nifuji A
Improved methods for immunohistochemical detection of BrdU in hard tissue
J Immunol Methods. 339(1):11-6, 2008.

1. Kanda T, Yoshida Y, Izu Y, Nifuji A, Ezura Y, Nakashima K, Noda M.
PlexinD1 deficiency induces defects in axial skeletal morphogenesis.
J Cell Biochem. 101(6):1329-37, 2007.

2. Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Ezura Y, Noda M.
Osteopontin is required for mechanical stress-dependent signals to bone marrow cells.
J Endocrinol. 193(2):235-43, 2007.

3. Hino K, Nakamoto T, Nifuji A, Morinobu M, Yamamoto H, Ezura Y, Noda M.
Deficiency of CIZ, a nucleocytoplasmic shuttling protein, prevents unloading-induced bone loss through the enhancement of osteoblastic bone formation in vivo.
Bone. 40(4):852-60, 2007.

4. Shimoyama A, Wada M, Ikeda F, Hata K, Matsubara T, Nifuji A, Noda M, Amano K, Yamaguchi A, Nishimura R, Yoneda T.
Ihh/Gli2 Signaling Promotes Osteoblast Differentiation by Regulating Runx2 Expression and Function.
Mol Biol Cell. 18(7):2411-8, 2007.

5. Komatsu K, Sanctuary C, Shibata T, Shimada A, Botsis J.
Stress-relaxation and microscopic dynamics of rabbit periodontal ligament.
J Biomech. 40(3):634-44, 2007.

6. Luan X, Ito Y, Holliday S, Walker C, Daniel J, Galang TM, Fukui T, Yamane A, Begole E, Evans C, Diekwisch TG.
Extracellular matrix-mediated tissue remodeling following axial movement of teeth.
J Histochem Cytochem. 55(2):127-40, 2007.

7. Suga T, Fukui T, Yamane A, Morito M.
Expressions of BMP2, BMP4, and their receptors during the development of mouse tongue muscle.
Jpn J Gerdontol. 22(3):280-7, 2007.

8. Yamane A. Fukui T.
Characteristics of masticatory and tongue muscles.
J Oral Biosci. 49(3): 206-10, 2007.

9. Tomohiro T, Yamane A, Asada Y.
Characterization of excess hard tissue occurring in the mesio-labial surface of the mandibular first molar in microphthalmic mouse.
Archs Oral Biol. 52(9):828-35, 2007.

10. Suga T, Fukui T, Shinohara A, Luan X, Diekwisch TGH, Morito M, Yamane A.
BMP2, BMP4, and their receptors are expressed in the differentiating muscle tissues of mouse embryonic tongue.
Cell Tissue Res. 329(1):103-17, 2007.

1. Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano T, Taketani Y, Nifuji A, Denhardt DT, Noda M.
Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts.
Endocrinology. 147(6):3040-9, 2006.

2. Hino K, Nifuji A, Morinobu M, Tsuji K, Ezura Y, Nakashima K, Yamamoto H, Noda M.
Unloading-induced bone loss was suppressed in gold-thioglucose treated mice.
J Cell Biochem. 99(3): 845-52, 2006.

3. Ishijima M, Ezura Y, Tsuji K, Rittling SR, Kurosawa H, Denhardt DT, Emi M, Nifuji A, Noda M.
Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss.
Exp Cell Res. 312(16):3075-83, 2006.

4. Akutsu S, Shimada A, Yamane A.
Transforming growth factor bs are up-regulated in the rat masseter muscle hypertrophied by clenbuterol, a b2 adrenergic agonist
Brit J Pharmacol. 147(4):412-421, 2006.

5. Matsumoto T, Akutsu S, Wakana N, Morito M, Shimada A, Yamane A.
The expressions of insulin-like growth factors, their receptors, and binding proteins are related to the mechanism regulating masseter muscle mass in the rat
Archs Oral Biol. 51(7):603-611, 2006.

6. Shibata T, Botsis J, Bergomi M, Mellal A, Komatsu K.
Mechanical behavior of bovine periodontal ligament under tension-compression cyclic displacements.
Eur J Oral Sci. 114: 74-82, 2006.

7. Shimada A, Komatsu K, Chiba M,
Effects of local injections of vasoactive drugs on eruption rate of incisor teeth in anesthetized rats.
Arch Oral Biol. 51(6): 449-456, 2006.

8. Shimada A, Komatsu K, Shibata T, Chiba M,
The effects of an intravenous infusion of Ringer's solution on eruption rates of incisor teeth in anesthetized rats.
Acta Odontol Scand. 64(1):16-20, 2006.

平成１７年（２００５年）

1. Morinobu M, Nakamoto T, Hino K, Tsuji K, Shen ZJ, Nakashima K, Nifuji A, Yamamoto H, Hirai H, Noda M.
The nucleocytoplasmic shuttling protein CIZ reduces adult bone mass by inhibiting bone morphogenetic protein-induced bone formation.
J Exp Med. 201(6):961-70, 2005

2. Kondo H, Nifuji A, Takeda S, Ezura Y, Rittling SR, Denhardt DT, Nakashima K, Karsenty G, Noda M.
Unloading Induces Osteoblastic Cell Suppression and Osteoclastic Cell Activation to Lead to Bone Loss via Sympathetic Nervous System.
J Biol Chem. 280(34):30192-200, 2005

3. Miyashita A, Komatsu K, Shimada A, Kokubo Y, Shimoda S, Fukushima S, Oida S.
Effect of remaining periodontal ligament on the healing-up of the implant placement.
J Hard Tissue Biol. 14(2):198-200, 2005.

4. Holliday S, Schneider B, Galang MT, Fukui T, Yamane A, Luan X, Diekwisch DGH.
Bones, teeth, and genes: A genomic homage to Harry sicher’s “axial movement of teeth”.
World J Orthod. 6(1):301-310, 2005

5. Yoshida T, Nagata J, Yamane A.
Growth factors and proliferation of cultured rat gingival cells in response to Cyclosporin A
J Periodont Res. 40(1):11-19, 2005

6. Wang X, Ito Y, Luan X, Yamane A, Diekwisch DGH.
Amelogenin sequence and enamel biomineralization in Rana pipiens.
J Exp Zool Mol Dev Evol. 304(2): 177-186, 2005

7. Yamane A, Akutsu S, Diekwisch TGH, Matsuda R.
Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damages in mdx mice
Am J Physiol. Cell Physiol. 289(1):C42-48, 2005.

8. Watanabe NY, Nakagwa Y, Akutsu S, Yamane A.
Effect of stress response to surgical procedures upon secretion of salivary immunoglobulin A in mice
Oral Sci Intl. 2(2):96-103, 2005

1. Nifuji A, Kellermann O, Noda M.
Noggin inhibits chondrogenic but not osteogenic differentiation in mesodermal stem cell line c1 and skeletal cells.
Endocrinology. 145(7):3434-42. 2004.

2. Usui M, Yoshida Y, Tsuji K, Oikawa K, Miyazono K, Ishikawa I, Yamamoto T, Nifuji A, Noda M.        
Tob deficiency superenhances osteoblastic activity after ovariectomy to block estrogen deficiency-induced osteoporosis.
Proc Natl Acad Sci U S A. 101(17):6653-8. 2004.

3. Chung CR, Tsuji K, Nifuji A, Komori T, Soma K, Noda M.
Micro-CT evaluation of tooth, calvaria and mechanical stress-induced tooth movement in adult Runx2/Cbfa1 heterozygous knock-out mice.
J Med Dent Sci. 51(1):105-13. 2004.

4. Ohyama Y, Nifuji A, Maeda Y, Amagasa T, Noda M.
Spaciotemporal association and bone morphogenetic protein regulation of sclerostin and osterix expression during embryonic osteogenesis.
Endocrinology. 145(10):4685-92, 2004.

5. Ohyama Y, Nemoto H, Rittling S, Tsuji K, Amagasa T, Denhardt DT, Nifuji A, Noda M.
Osteopontin-deficiency suppresses growth of b16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures.
J Bone Miner Res. 19(10):1706-11, 2004.

6. Maeda Y, Tsuji K, Nifuji A, Noda M.
Inhibitory helix-loop-helix transcription factors Id1/Id3 promote bone formation in vivo.
J Cell Biochem. 93(2):337-344, 2004.

7. Komatsu K, Shibata T, Shimada A, Viidik A, Chiba M.
Age-related and regional differences in the stress-strain and stress-relaxation behaviours of the rat incisor periodontal ligament.
J Biomech. 37(7): 1097-1106, 2004.

8. Komatsu K, Kanazashi M, Shibata T, Shimada A, Viidik A, Chiba M.
Effects of age on the stress-strain and stress-relaxation properties of the rat molar periodontal ligament.
Archs Oral Biol. 49(10): 817-824, 2004.

9. Yamane A, Amano O, Urushiyama T, Nagata J, Akutsu S, Fukui T, Diekwisch, TGH.
Exogenous hepatocyte growth factor inhibits myoblast differentiation by inducing myf5 expression and suppressing myoD expression in an organ culture system of embryonic mouse tongue.
Eur J Oral Sci. 112(2):177-181, 2004.

10. Urushiyama T, Akutsu S, Miyazaki J.-I, Fukui T, Diekwisch TGH, Yamane A.
Change from a hard to soft diet alters the expression of insulin-like growth factors, their receptors, and binding proteins in association with atrophy in adult mouse masseter muscle
Cell Tissue Res. 315(1):97-105, 2004.

11. Fukui T, Akutsu S, Hirashita A, Oida S, Diekwisch TGH, Yamane A.
Effects of exogenous bone morphogenetic protein 2 on the formation of mouse molar tooth germ.
J Oral Biosci. 46(6):530-535, 2004.

12. Saito T, Fukui K, Akutsu S, Nakagawa Y, Ishibashi K, Nagata J, Shuler CF, Yamane A.
Effects of diet consistency on the expression of insulin-like growth factors, their receptors, and binding proteins during the development of rat masseter muscle soon after weaning.
Archs Oral Biol. 49(10):777-782, 2004.

13. Nagata J, Yamane A.
Progress of cell proliferation in striated muscle tissues during the development of mouse tongue.
J Dent Res. 83(12):926-929, 2004.

14. Fukui T, Akutsu S, Hirashita A, Oida S, Diekwisch TGH, Yamane A.
Effects of exogenous bone morphogenetic protein 2 on the formation of mouse molar tooth germ.
J Oral Biosci. 46(6):530-535, 2004.

15. Shibata T, Komatsu K, Shimada A, Shimoda S, Oida S, Kawasaki K, Chiba M.
Effects of alendronate on restoration of biomechanical properties of periodontium in replanted rat molars.
J Periodont Res. 39(6):405-414, 2004.

16. Shinohara J, Shibata T, Shimada S, Komatsu K.
The biomechanical properties of the healing periodontal ligament of replanted rat mandibular incisors.
Dent Traumatol. 20(4): 212-221, 2004.

17. Shimada A, Shibata T, Komatsu K.
Relationship between the tooth eruption and regional blood flow in angiotensin II-induced hypertensive rats.
Archs Oral Biol. 49(4): 427-433, 2004.

平成１５年（２００３年）

1. Yagi K, Tsuji K, Nifuji A, Shinomiya K, Nakashima K, DeCrombrugghe B, Noda M.
Bone morphogenetic protein-2 enhances osterix gene expression in chondrocytes.
J Cell Biochem. 88 :1077-1083, 2003.

2. Kitahara K, Shijima M, Rittling SR, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, Noda M.
Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation.
Endocrinology. 144:2132-40, 2003.

3. Takamoto M, Tsuji K, Yamashita T, Sasaki H, Yano T, Taketani Y, Komori T, Nifuji A, Noda M.
Hedgehog signaling enhances core-binding factor a1 and receptor activator of nuclear factor-kappaB ligand (RANKL) gene expression in chondrocytes.
J Endocrinol. 177:413-421, 2003.

4. Salingcarnboriboon R, Yoshitake H, Tsuji K, Obinata M, Amagasa T, Nifuji A, Noda M.
Establishment of tendon-derived cell lines exhibiting pluripotent mesenchymal stem cell-like property.
Exp Cell Res. 287:289-300, 2003.

5. Morinobu M, Ishijima M, Rittling SR, Tsuji K, Yamamoto H, Nifuji A, Denhardt DT, Noda M.
Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo.
J Bone Miner Res. 18:1706-1715, 2003.

6. Fukui T, Yamane A, Komatsu K, Chiba M.
Restoration of mechanical strength and morphological features of the periodontal ligament following orthodontic retention in the rat mandibular first molar.
Eur J Orthod. 25:167-174, 2003.

7. Saito T, Akutsu S, Urushiyama T, Ishibashi K, Nakagawa Y, Shuler C.F, Yamane A.
Changes in the mRNA expressions of insulin-like growth factors, their receptors and binding proteins during the postnatal development of rat masseter muscle
Zool Sci. 20(4): 441-447, 2003.

8. Wakana N, Akutsu S, Yamane A.
Effects of clenbuterol, a b2-adrenergic agonist, on the myofiber diameter, fiber type, and expressions of insulin-like growth factors in the adult mouse masseter muscle
Jpn J Oral Biol. 45(6):418-427, 2003.

9. Shimada A, Shibata T, Komatsu K, Chiba M.
The effects of intrusive loading on axial movements of impeded and unimpeded rat incisors: Estimation of the eruptive force.
Archs Oral Biol. 48(5): 345-351, 2003.

1. Yumoto K, Ishijima M, Rittling SR, Tsuji K, Tsuchiya Y, Kon S, Nifuji A, Uede T, Denhardt DT, Noda M.
Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice.
Proc Natl Acad Sci U S A. 99(7):4556-4561, 2002.

2. Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Noda M.
Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice.
J Bone Miner Res. 17:661-667, 2002.

3. Asou Y, Nifuji A, Tsuji K, Shinomiya K, Olson EN, Koopman P, Noda M.
Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage.
J Orthop Res. 20:827-833, 2002.

4. Usui M, Yoshida Y, Yamashita T, Tsuji K, Isao I, Yamamoto T, Nifuji A, Noda M.
Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis.
J Bone Miner Res. 17:1026-1033, 2002

5. Shen ZJ, Nakamoto T, Tsuji K, Nifuji A, Miyazono K, Komori T, Hirai H, Noda M.
Negative regulation of bone morphogenetic protein/Smad signaling by Cas-interacting zinc finger protein in osteoblasts.
J Biol Chem. 277:29840-29846, 2002.

6. Kashimada K, Yamashita T, Tsuji K, Nifuji A, Mizutani S, Nabeshima Y, Noda M.
Defects in growth and bone metabolism in klotho mutant mice are resistant to GH treatment.
J Endocrinol. 174:403-410, 2002.

7. Komatsu K., Kanazashi M, Arai T, Chiba M.
Effects of hydrocortisone and b-aminopropionitrile on stress-strain and stress-relaxation behaviors, and birefringent retardation of collagen fibres in the rat incisor periodontal ligament.
Connect Tissue Res. 43(4):581-588, 2002.

8. Komatsu K, Mosekilde L, Viidik A, Chiba M.
Polarized light microscopic analyses of collagen fibers in the rat incisor periodontal ligament in relation to areas, regions, and ages.
Anat Rec. 268(4):381-387, 2002.

9. Yamane A, Saito T, Ohnuki Y, Saeki Y.
Changes in mRNA expression of nicotinic acetylcholine receptor subunits during embryonic development of mouse masseter muscle
Zool Sci. 19(2):207-213, 2002.

10. Yamane A, Urushiyama T, Diekwisch TGH.
Roles of insulin-like growth factors and their binding proteins in the differentiation of mouse tongue myoblasts
Int J Dev Biol. 46(6): 807-816, 2002.

11. Saito T, Ohnuki Y, Yamane A, Saeki Y.
Effects of diet consistency on the myosin heavy chain mRNAs of rat masseter muscle during postnatal development
Archs Oral Biol. 47(2):109-115, 2002.

12. Amano O, Yamane A, Shimada M, Koshizumi U, Nakamura T, Iseki S.
Hepatocyte growth factor is essential for migration of myogenic cells and promotes their proliferation during the early periods of tongue myogenesis in mouse embryos
Dev Dyn. 223(2):169-179, 2002.

13. Saito T, Ohnuki Y, Saeki Y, Ishibashi K, Yanagisawa K, Yamane A.
Postnatal changes in the nicotinic acetylcholine receptor subunits in rat masseter muscle
Archs Oral Biol. 47(5): 417-421, 2002.

14. Satchell PG, Anderton X, Ryu OH, Luan X, Ortega AJ, Opamen R, Berman BJ, Witherspoon DE, Gutmann JL, Yamane A, Zeichner-David M, Simmer JP, shuler CF, Diekwisch TGH.
Conservation and variation in enamel protein distribution during tooth development across vertebrates
J Exp Zool. 294(2): 91-106, 2002.

15. Diekwisch TGH, Bermanb BJ, Anderton X, Gurinsky B, Ortega AJ, Satchell PG, Williams M, Arumugham C, Luan X, Mcintosh JE, Yamane A, Carlso, DS, Sire J.-Y, Simmer JP, Shuler CF.
Membranes, minerals, and proteins of developing vertebrate enamel
Microsc Res Tech. 59(5): 373-395, 2002.

1. Nemoto H, Rittling SR, Yoshitake H, Furuya K, Amagasa T, Tsuji K, Nifuji A, Denhardt DT, Noda M.
Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues.
J Bone Miner Res. 16:652-659, 2001.

2. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Nifuji A, Noda M.
Dexamethasone enhances SOX9 expression in chondrocytes.
J Endocrinol. 169(3):573-579, 2001.

3. Sekiya I, Koopman P, Tsuji K, Mertin S, Harley V, Yamada Y, Shinomiya K, Nifuji A, Noda M. 
Transcriptional suppression of SOX9 expression by retinoic acid in chondrocytes.
J Cell Biochem. 81:71-78, 2001.

4. Asou Y, Rittling SR, Yoshitake H, Tsuji K, Shinomiya K, Nifuji A, Denhardt DT, Noda M.
Osteopontin facilitates angiogenesis, accumulation of osteoclasts and resorption in ectopic bone.
Endocrinology. 142:1325-1332, 2001.

5. Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma Y, Tsuji K, Hruska KA, Higashio K, Enomoto S, Nifuji A, Rittling SR, Noda M.
Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin.
J Biol Chem. 276:13065-13071, 2001.

6. Ishijima M, Rittling SR, Yamashita T, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, Noda M.
Enhancement of Osteoclastic Bone Resorption and Suppression of Osteoblastic Bone Formation in Response to Reduced Mechanical Stress do not Occur in the Absence of Osteopontin.
J Exp Med. :193, 399-404, 2001.

7. Nifuji A, Miura N, Kato N, Kellermann O, Noda M.
Bone morphogenetic protein regulation of forkhead/winged helix transcription factor Foxc2 (Mfh1) in a murine mesodermal cell line C1 and in skeletal precursor cells.
J Bone Miner Res. 16:1765-1771, 2001.

8. Komatsu K, Chiba M.
Synchronous recording of load-deformation behaviour and polarized-light microscopic images of the rabbit incisor periodontal ligament during tensile loading.
Archs Oral Biol. 46(10):929-937, 2001.

9. Yamazaki Y, Komatsu Arai T, Chiba M.
The effect of a high-carbohydrate diet on the stress-strain behavior of the periodontal ligament of the distal root of the mandibular first molar in hamsters.
J Periodont Res. 36(5): 301-308, 2001.

10. Yamane A, Ohnuki Y, Saeki Y.
Developmental changes of nicotinic acetylcholine receptor in mouse tongue striated muscle
J Dent Res. 80(9):1840-1844, 2001

1．柴田達也、山根　明、島田明美、永田純史、小松浩一郎     
薬物動態シミュレーションプログラムを用いた実習方法　−歯学部薬理学実習への応用−
日本薬理学雑誌　127(6): 467-471, 2006

2．島田明美、柴田達也、小松浩一郎、山根　明           
薬理学early exposureへの薬物動態シミュレーションソフトウェアの利用.
歯科医学教育学雑誌　21(1): 70-76, 2006

1. Yamane A.
Embryonic and postnatal development of masticatory and tongue muscles
Cell Tissue Res. 322(2): 183-189, 2005

2. 二藤　彰
骨の再生
化学と生物　vol43: 193-197, 2005

3. 小松浩一郎
歯根膜の生体力学的反応と組織構造との関係. (Relation between biomechanics of the periodontal ligament and its microscopic dynamics)
The Journal of Dental Engineering. No. 155, 31-34, 2005

4. 山根　明、小川　匠、斎藤　高、塩見信行、福島俊士
南カリフォルニア大学歯学部における問題解決型学習(PBL)カリキュラムについて
歯科医学教育学雑誌　21(1): 60-69, 2005

5. 小川　匠、山根　明、馬場一美、羽毛田　匡、水口　一、Glenn T Clark、福島俊士
南カリフォルニア大学歯学部における補綴学の問題解決型学習（PBL）の現状

1. 山根　明、永田純史、阿久津覚誠、天野　修
増殖因子による舌横紋筋発生制御機構
J Oral Biosci. 46(2): 107-115, 2004

2. 天野　修、山根　明
口腔組織発生における肝細胞増殖因子の機能
口腔組織培養学会誌　13(2):1-11, 2004

1. Yamane A, Amano O, Slavkin HC.
Insulin-like growth factors (IGFs), hepatocyte growth factor (HGF), and transforming growth factor a (TGFa) in mouse tongue myogenesis
Dev Growth Differ. 45(1): 1-6, 2003

2. 野田政樹、大山巌雄、辻邦和、二藤　彰
オステオポンチンと癌骨転移
The Bone. vol17, 151-154, 2003

3. 野田政樹、近藤久貴、日野和典、辻邦和、二藤　彰
メカニカルストレスと細胞外基質タンパク
The Bone. vol17, 457-460, 2003

4. 野田政樹、湯本健司、森信幹彦、辻邦和、二藤　彰
関節リウマチに関する‘オステオポンチン’研究の最新動向
日本臨床　vol61, 887-890, 2003

5. 野田政樹、森信幹彦、八木啓介、北原圭一郎、辻邦和、二藤　彰
骨再生と細胞分化
血液・免疫・腫瘍　vol8, 52-56, 2003

6. 野田政樹、辻邦和、二藤　彰
骨の組織学から見たトピックスとしてのオステオポンチン
Clinical Calcium. vol13(4): 464-466, 2003

7. 二藤　彰
骨疾患からみた骨形態形成の分子制御
骨粗鬆症治療　vol2: 273-278, 2003

8. 漆山登喜、大貫芳樹、阿久津覚誠、三枝木泰丈、山根　明
アガロースゲルを一次元電気泳動時に用いた二次元電気泳動法による筋タンパク質発現の解析
鶴見歯学 29(3): 297-304, 2003

1. 野田政樹、鹿島田健一、前田由紀子、湯本健司、辻邦和、二藤　彰
骨再生
小児外科　vol 34 : 104-109, 2002

2. 野田政樹、石島旨章、高本真弥、辻邦和、二藤　彰
間葉系幹細胞による骨再生
Clinical Calcium. 12(2): 9-14, 2002

3. 野田政樹、辻邦和、森信幹彦、石島旨章、二藤　彰
血管形成に関わる遺伝子—osteopontinと骨
Clinical Calcium. 12(3): 363-367, 2002

4. 野田政樹、辻邦和、石島旨章、高本真弥、臼井通彦、鹿島田健一、二藤　彰
骨のリモデリング
日本臨床　６０巻 p34-39, 2002

5. 野田政樹、石島旨章、森信幹彦、辻邦和、二藤　彰
骨代謝シグナルとしてのオステオポンチン
実験医学　vol17（増刊）, 2465-2468, 2002

6. 山根　明、漆山登喜、阿久津覚誠、大井田新一郎
マウス胎仔の舌を用いた器官培養法